منابع مشابه
Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides.
Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.
متن کاملEfficient DBU accelerated synthesis of 18 F - labelled trifluoroacetamides † Antonio Bermejo
Due to the favourable properties of fluorine, approximately one fifth of newly registered small drugmolecules are organofluorine compounds. Moreover, the artificial isotope F (t1/2 109.8 min) has suitable nuclear properties for in vivo imaging in human subjects using positron emission tomography (PET). Hence, there is a large demand for efficient fluorination methodologies in both medicinal and...
متن کاملSynthesis of 18F-labelled 2-fluoro-1,4-quinones using acetylhypofluorite.
The fluorination of 1,4-benzo- and naphthoquinones using [18F]acetylhypofluorite is described. For compounds with electron-donating substituents fair to good radiochemical yields have been reached.
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چکیده ندارد.
Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold.
Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental data on the involvement of COX isoform COX-2 in tumour development and progression, as well as the observed overexpression of COX-2 in a variety...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2016
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c6cc08535k